Nomination Committee

The duties of the Nomination Committee include the preparation and drafting of proposals regarding the election of members of the board of directors, the chairman of the board of directors, the chairman of the general meeting and auditors.

According to the instructions for Nomination Committee in Ascelia Pharma (publ), adopted at the annual general meeting held on 23 November 2018, the Nomination committee shall consist of four members representing the three largest shareholders per the end of March, together with the chairman of the board of directors. The three largest shareholders refer to the ownership group registered or in any other way known shareholders as per the end of March.

The nomination committee, for the 2019 Annual General Meeting, has the following composition:

  • Jørgen Thorball, chairman of the Nomination Committee, appointed by Sunstone Life Science Ventures II K/S;
  • Nils Lorentzen, appointed by CMC SPV of 3 April 2017 AB;
  • Håkan Nelson, appointed by Øresund Healthcare Capital K/S; and
  • Peter Benson, chairman of the board of directors.

Mangoral

Our lead candidate Mangoral is a liver imaging drug (i.e. a liver specific contrast agent) being developed for detection and localization of potential liver metastases, using Magnetic Resonance Imaging (“MRI”) in patients where use of the current gold standard gadolinium-based contrast agents (“GBCAs”) may be medically inadvisable or cannot be administered. Mangoral is currently ready for Phase III clinical development.

Oncoral

Oncoral is a novel tablet-based formulation of the well-known chemotherapeutic agent irinotecan, intended for the treatment of advanced gastric (stomach) cancer. Irinotecan is today mainly used for treating metastasized colorectal cancer. Although irinotecan is currently not approved for treating gastric cancer in the United States and in the EU, there is off-label use for this indication. Oncoral has completed Phase I studies with encouraging results and is ready for Phase II studies.

DEVELOPMENT PLAN

Ascelia has established a development program for lead candidate Mangoral, consisting of a pivotal Phase III efficacy study and two supportive studies. The clinical development strategy for Oncoral, Ascelia´s second drug candidate, is to obtain Phase II data and then to partner for the further development.